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Recent NEWS
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May 3, 2021
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Clarifying Polycomb targeting during XCI:
Colognori D, Sunwoo H, Wang D, Wang CY, Lee JT. 2021. Xist Repeat A contributes to early recruitment of Polycomb complexes during X-chromosome inactivation. Dev Cell 56(9):1236-1237. Read |
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March 15, 2021
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Honored to receive the 2020 Cozzarelli Prize for the discovery that B2 and ALU RNAs are SELF-CLEAVING RIBOZYMES! Congratulations to all coauthors!
Hernandez AJ, Zovoilis A, Cifuentes-Rojas C, Han L, Bujisic B, Lee JT. 2019. B2 and ALU retrotransposons are self-cleaving ribozymes whose activity is enhanced by EZH2. Proc Natl Acad Sci U S A. 2019 Dec 23. pii: 201917190. doi: 10.1073/pnas.1917190117. Read. |
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March 15, 2021
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PhD student Andrea Kriz shows us how to create megadomains and superloops on the active X (Xa) — and get away with it !
Kriz AJ, Colognori D, Sunwoo H, Nabet B, Lee JT. 2021. Balancing cohesin eviction and retention prevents aberrant chromosomal interactions, Polycomb-mediated repression, and X-inactivation. Molecular Cell 10.1016/j.molcel.2021.02.031. Read |
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Feb 15, 2021
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We welcome Emily Xia to the lab!
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Jan 4, 2021
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Michael and Roy publish their breakthrough understanding of RNA's interaction with Polycomb! -- resolving the mystery of why RNA-PRC2 complexes occur within active genes, and how specificity is achieved.
Rosenberg M†, Blum R†, Kesner B, Aeby E, Garant J-M, Szanto A, and Lee JT. 2021. Motif-driven interactions between RNA and PRC2 are rheostats that regulate transcription elongation. Nature Struct Mol Biol. 10.1038/s41594-020-00535-9. Read News coverage: https://www.eurekalert.org/pub_releases/2021-01/mgh-srl010421.php |
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Jan 4, 2021
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Happy New Year!
We welcome Niklas Grimm to the lab! |
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Dec 18, 2020
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Congratulations to our PEW Latin American Fellow, Rodrigo, on becoming Assistant Professor at Andres Bello University, Chile! He is starting with funding both the Pew Foundation and the Chilean government.
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Dec 15, 2020
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Nico Simonet joins our lab! Welcome.
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Aug 30, 2020
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Farewell to Tom Dial !!
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Aug 17, 2020
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X chromosomes play TAG --> YOU'RE IT !! See how sex chromosomes decide who will stay 'ON' through PAIRING, an RNA decapping enzyme, and CTCF:
Aeby E, Lee H-G †, Lee Y-W †, Kriz A, del Rosario BC, Oh HJ, Boukhali M, Haas W, and Lee JT. 2020. Decapping enzyme 1A breaks X-chromosome symmetry by controlling Tsix elongation and RNA turnover. Nature Cell Biology, doi.org/10.1038/s41556-020-0558-0. Read for free Congrats to Eric Aeby et al. !! |
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June 11, 2020
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Congrats to David and Hongjae on another outstanding collaboration! Be confused no more about the relationship between Xist, Polycomb recruitment, and gene silencing:
Colognori D, Sunwoo H, Wang D, Wang CY, Lee JT. 2020. Xist Repeats A and B Account for Two Distinct Phases of X Inactivation Establishment. Dev Cell. doi: 10.1016/j.devcel.2020.05.021. Read |
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April 14, 2020
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Tom Dial successfully Zoom-defends his thesis! Congratulations, Dr. Dial!
And thanks to Professors Nancy Kleckner, Craig Hunter, and Brian Liau for serving on the thesis committee. |
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Feb. 10, 2020
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Excited to share an important finding for the X reactivation community: Surprising tolerance to increased X chromosome dosage in multiple tissues. Read.
Yang L, Yildirm E, Kirby JE, Press W, and Lee JT. 2020. Widespread organ tolerance of Xist loss and X reactivation except under chronic stress in the gut. PNAS 117: 4262-4272. |
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Jan. 5, 2020
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Welcome to the Lab, Antonino!
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Dec. 26, 2019
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We publish our surprising conclusion: SINE retrotransposons, B2 and ALU, are SELF-CLEAVING RIBOZYMES!
Hernandez AJ, Zovoilis A, Cifuentes-Rojas C, Han L, Bujisic B, Lee JT. 2019. B2 and ALU retrotransposons are self-cleaving ribozymes whose activity is enhanced by EZH2. Proc Natl Acad Sci U S A. 2019 Dec 23. pii: 201917190. doi: 10.1073/pnas.1917190117. Read. |
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Oct. 1, 2019
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Welcome, Anna!
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Sept. 14, 2019
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FRAXA Biotech Games a success! Our lab had a great time meeting families and fellow competitors.
Photo: William Press, Hungoo Lee, Tom Dial, and Elizabeth Kraeutler. |
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Sept. 13, 2019
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Really excited about our collaboration with Roy Perlis, Steve Sheridan et al. First publication now online:
Jagtap S, Thanos JM, Fu T, Wang J, Lalonde J, Dial TO, Feiglin A, Chen J, Kohane I, Lee JT, Sheridan SD, Perlis RH. (2019) Aberrant mitochondrial function in patient-derived neural cells from CDKL5 deficiency disorder and Rett Syndrome. Hum Mol Genet. 2019 Sep 13. pii: ddz208. doi: 10.1093/hmg/ddz208. Read |
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Aug 30, 2019
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We say farewell and good luck to our PhD students -- Chen-Yu Wang who will become postdoc in Gord Fishell's Lab, and David Colognori who will become postdoc in Jennifer Doudna's Lab!
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Aug 16, 2019
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Chen-Yu is unstoppable. Publication #3! Wang CY, Brand H, Shaw ND, Talkowski ME, and Lee JT. (2019) Role of the Chromosome Architectural Factor SMCHD1 in X Chromosome Inactivation, Gene Regulation, and Disease in Humans. Genetics ePub doi: 10.1534/genetics.119.302600.
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July 11, 2019
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Congratulations to Andrea on an NIH predoctoral award! She is now anointed by both NSF and NIH. Great start to a scientific career!
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July 3, 2019
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Another of Chen-Yu's masterpieces! A chromosome-folding pathway that enables Xist RNA to spread: (1) Xist recruits Polycomb PRC1, (2) PRC1 fuses A/B compartments, (3) SMCHD1 merges the resulting S1/S2 structures, (4) and then Xist spreads across the X without getting "stuck".
Read here: https://rdcu.be/bIriO |
Wang CY, Colognori D†, Sunwoo H†, Wang D, and Lee JT. (2019) PRC1 collaborates with SMCHD1 to fold the X-chromosome and spread Xist RNA between chromosome compartments. Nat Communications 10:2950. doi.org/10.1038/s41467-019-10755
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July 1, 2019
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Katya Nizovtseva, Hao Yin, and Elizabeth Kraeutler join our lab. Welcome!
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May 30, 2019
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A bumper crop of PhD students: Chen-Yu Wang, John Froberg, and David Colognori at the Graduation Hooding Ceremony. Congratulations to our outstanding students!!
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May 14, 2019
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Hongjae Sunwoo "graduates" from the lab
-- off to Intellia he goes! He will be missed. |
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May 1, 2019
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We are thrilled that David Colognori successfully defended his PhD thesis today!
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April 24, 2019
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Our iBiology Lectures on X-chromosome inactivation are now online!
3 Lectures for the general public and interested students. Watch here. |
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April 22, 2019
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A warm welcome to Vered Levy, who just joined us as Lab Manager!
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April 11, 2019
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Congratulations to Hungoo on his FRAXA postdoc award!
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April 3, 2019
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Congrats to Chen Yu who successfully defends his PhD today!
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March 31, 2019
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We say farewell to Attila Szanto and Teddy Jegu!
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Feb. 28, 2019
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Congratulations to David and Hongjae on a great finding: Although Xist recruits Polycomb complexes, Xist also depends on Polycomb complexes to continue to spread along the Xi.
Colognori D †, Sunwoo H †, Kriz A, Wang C-Y, and Lee JT. (2019) Xist deletional analysis reveals an interdependency between Xist RNA and Polycomb complexes for spreading along the inactive X. Molecular Cell 10.1016/j.molcel.2019.01.015. Read |
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Jan. 24, 2019
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Brian and Andrea have just published a novel CTCF modification!
Del Rosario BC †, Kriz AJ †, Del Rosario AM, Anselmo A, Fry CJ, White FM, Sadreyev RI, Lee JT. (2019) Exploration of CTCF post-translation modifications uncovers Serine-224 phosphorylation by PLK1 at pericentric regions during the G2/M transition. Elife. 2019 Jan 24;8. pii: e42341. doi: 10.7554/eLife.42341. Pre-proof PDF here. |
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Jan. 21, 2019
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The 2 faces of Xist RNA: (1) Attractant for silencers, and (2) Repellant for activators. Our new paper shows how it repels SWI/SNF-BRG1 from the inactive X. Congratulations to Teddy and Roy!! To read for free, click here.
Jegu, T. †, Blum R. †, Cochraine, J.C., Yang, L., Wang, C.Y., Gilles, M.-E., Colognori, D., Szanto, A., Marr, S.K., Kingston, R.E., and Lee, J.T. (2019) Xist RNA antagonizes the SWI/SNF chromatin remodeler, BRG1, on the inactive X chromosome. Nature Structural & Molecular Biology 10.1038/s41594-018-0176-8. |
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Jan. 11, 2019
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Our Rett Syndrome work has been featured in the Atlas of Science. Click here to read it!
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Dec 21, 2018
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Montse Michelman, our lab manager of 14 years, has retired!
And we wish Eric Aeby a safe return to Switzerland and a new beginning! |
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Dec. 1, 2018
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We welcome Uri Weissbein (postdoc) to the lab.
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Nov. 27, 2018
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Our BioRxiv paper is now published! Froberg JE, Pinter SF, Kriz AJ, Jegu T, and Lee JT. (2018) Megadomains and superloops form dynamically but are dispensable for X chromosome inactivation and gene escape. Nature Communications 9, 5004.
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Oct. 1, 2018
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We welcome Lu Han (postdoc) and Carlos Rivera (student) to the lab.
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Sept. 30, 2018
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Our Rett Syndrome expert, Lieselot Carrette, becomes a Visiting Scientist at Scripps, La Jolla.
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Sept. 17,
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John Froberg successfully defended his PhD today -- Congratulations!
Wishing you all the best as postdoc in the Macklis Lab (Harvard). |
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Sept. 14, 2018
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Lab alumnus, Ruslan Sadreyev (center), is promoted to Assistant Professor of Pathology, MGH. Well done!
Lab reunion at CSH Epigenetics - with Stefan Pinter, Montserrat Anguera, Kavitha Sarma, and Jeannie Lee. |
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Sept. 5, 2018
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Our worm paper is published - Congrats to Arneet! Multiple Histone Methyl-Lysine Readers Ensure Robust Development and Germline Immortality in Caenorhabditis elegans. Saltzman AL, Soo MW, Aram R, Lee JT. Genetics. 2018 Sep 5.
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July 23, 2018
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Congrats to postdoctoral fellow, Lieselot Carrette, on a new publication!
Tsix–Mecp2 female mouse model for Rett syndrome reveals that low-level MECP2 expression extends life and improves neuromotor function. http://www.pnas.org/content/early/2018/07/17/1800931115 … |
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July 22, 2018
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We have a new website!
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July 9, 2018
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Check out John Froberg's work:
X-Chromosome without Borders: Firre(d) up about Dxz4! . .. and our lab's 1st pre-print in BioRxiv! www.biorxiv.org/content/early/2018/07/08/364893 |
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June 7, 2018
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Chen Yu Wang's paper is now published!
Folded like Origami - is the Inactive X chromosome by SMCHD1: https://www.cell.com/cell/fulltext/S0092-8674(18)30584-1 |
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